Reverse autoimmune disease by selectively shutting down the immunity

#scitisfaction

They discovered in recent years that tagging molecules with a sugar known as N-acetylgalactosamine (pGal) could mimic this process, sending the molecules to the liver where tolerance to them develops.

“The idea is that we can attach any molecule we want to pGal and it will teach the immune system to tolerate it,” explained Hubbell. “Rather than rev up immunity as with a vaccine, we can tamp it down in a very specific way with an inverse vaccine.”

pme.uchicago.edu/news/inve…

September 16, 2023

Learned: force Firefox to print non .txt files instead of downloading them

#itnuts

Use prefix view-source: before the url. This allows to quickly check the contents of curl-to-bash install scripts like this:

view-source:https://pyenv.run/

September 8, 2023

The longest word one can type on the first row

#interrobang

Spoiler:

Eriwtureiwotuqwriqwerewreqqwioop

The article lists more comprehensible words as well :)

rubenerd.com/the-longe…

August 26, 2023

Oldest still alive domain names

#itnuts

https://en.wikipedia.org/wiki/List_of_the_oldest_currently_registered_Internet_domain_names

August 25, 2023

Geometry of music

#artinstinctive

2 on one wiki page

One of the papers of Tymoczko was the first music theory paper published by the journal Science.

His web page is very interactive: dmitri.mycpanel.princeton.edu/index.htm…

August 13, 2023

#interrobang

August 12, 2023

Bidirectional tcp - udp forwarding oneliner

#itnuts

if you ever wondered how to connect to Wireguard server via SSH:

mkfifo /tmp/fifo
nc -l -p 5679 < /tmp/fifo | nc -u 127.0.0.1 5678 > /tmp/fifo

https://superuser.com/questions/53103/udp-traffic-through-ssh-tunnel

August 9, 2023

Some people just inspire

#itnuts

kognise.dev

She is 17 and knows how CPUs work: cpu.land , also how networking works: github.com/kognise/a… , plays cello, composes music and piloting aircrafts, and I guess many more…

im-press-ive

August 9, 2023

The Website Existential Crisis

#itnuts

Redesigning a website goes beyond applying a fresh coat of CSS: it can (and maybe should) make your project go through an existential crisis. You need to put words on who you are, what you do, for whom, and who you’re talking to. It requires stepping out of your comfort zone but it rewards you with a better compass for your project.

ergaster.org/posts/202…

August 9, 2023

Mark Pilgrim's case

#itnuts HN

It’s funny how after 15 years Mark Pilgrim re-appeared in my infospace, provided that he literally removed all his presence / websites / repos / etc from web in 2011.

www.hanselman.com/blog/410-…

August 8, 2023